Its depending on the brand, and if you have cartridges with or without integrated printheads, with integrated printheads its much easyer and it spills less ink, but the cleaning you can mean not the clean function on the printer self but to clean with a cartridge flush , i have done it several times with a coffee saucer with some lukewarm tap water, years ago by canon printers perfect but there is the loose printhead but there is a special flush-alcohol for if its clogged but after that if you print not much you can then best printhead thus it maintained flush him briefly just after the changing of cartridges and especially if you himself refilled it keeps closing rubbers clean where the cartridges are placed so that it stays clean , but as soon if a printhead is for a more then short time glogged if it is dry the printhead fails due to lack of cooling most times the refill can comes too late. but if only neccesary to clean when clogged nozzles use always a good special cartridge flush
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