I have had a similar problem a few times and in desperation the first time, I found the file on the hard drive, opened the file and began deleting the many programmes it contained piecemeal. Long and tedious work...
When I grew bored I closed the file and was able to delete it.
Trying it again on other unwanted files I found I could delete all the programmes the file contained but not the file itself.
There are clean up utilities available for download - the free versions are a bit limited but the paid for versions are reputedly quite good. I have used the free version of CCleaner for a few years without problems.
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