I HAVE A NIKON 35MM FILM SCANNER LS-40-ED SERIAL NUMBER ;228462 AND I REQUIRE THE APPROPRIATE SOFTWARE TO LOAD ONTO MY APPLE MAC G4 DESKTOP COMPUTER (OPERATING SYSTEM X TIGER.)VERSION 10.4.6 2Z691-5811-A I LOOK FORWARD FOR YOUR ASSISTANCE SO I CAN START SCANNING MY SLIDES AND NEGATIVES AGAIN MR CYRIL JONES

For my scanner I bought Silverfast. It is available for Windows and MAC.
Just look for a demo on this site
Silverfast scanner software for Nikon

According to the Nikon site the software for the Coolscan is not compatible for Mac OS Lion, you need to purchase silverfast to get it to work see http://www.scandig.com/filmscanner/nikon/nikon-coolscan-v-ed.html silverfast can be bought from http://www.silverfast.com/ you can download a demo from here to see if it works.

http://www.sebsgarage.com/2005/11/cleaning-nikon-coolscan-iv-ed-ls-40-film-scanner

You can download the Vista Driver at this link: 4.0.3 full version - Vista only

If this information was helpful, please give me a big thumbs up when you rate my answer.

I read this forum entry and it solved my problem also:

http://www.pcreview.co.uk/forums/thread-1936922.php

I originally had the same problem but with a G5. Since Nikon never updated the software for the LS2000 to work with Apple I ended up buying a FR1SX adapter from RATOC Systems: http://www.ratocsystems.com/english/products/FR1SX.htmlwhich connects the SCSI pins to a Firewire cable. Then I purchased the VueScan software from http://www.hamrick.com/vsm.html. The scanner worked for several years with this combination. 

Nikon supports mac. You'll want to go to nikon.com for more details.

do one thing i send you a link in that you download the driver and software after that you can work http://www.gfdi.fsu.edu/staticpages/index.php?page=nikonls1000

Yes - get hold of an Adaptec USB2XCHANGE SCSI-USB cable and download Vuescan software (www.hamrick.com). This works perfectly on LS2000 - Macbook Pro combo. 

Try these links:

http://www.silverfast.com/product/fr.html?product=436
http://www.xpvistasite.com/super_coolscan_5000_ed_13548.htm

'hope that helped.