Can i clean a throttle body on a 2.4 2007 saturn vue hybrid with a throttle body cleaner while it is on the car,and should i open the throttle?

It is integrated into the throttle body with the control motor.

View this video for Saturn Vue T/Body issues.:

https://youtu.be/1CEJ9TNK8O8

Yes that is how it is done, just soak it good and wipe out the bore with a soft cotton rag.

To be caused from several things 1 if the throttle body butterfly has carbon buildup that will cause it throttle body needs to be clean to the mass air sensor is dirty and needs to be clean. They use a special cleaner for mass air in a can do not touch the sensor with your hand our fingers. 3 you have a vacuum leak somewhere

If you used spray cleaner on the throttle plate or into the bore, you may have damaged the gears or motor in the throttle body. The vehicle shouldn't need any further initialization unless the throttle body has been replaced or the powertrain control module has been reprogrammed or replaced.

Take it to a qualified repair shop , Thinking ??? Also was thinking the MAF sensor or Intake Air sensor might be faulty . TESTING IS THE WAY TO A PROPER FIX !!!!!

Your Idle Air Control (IAC) valve may be dirty with carbon, simple fix with throttle body cleaner through the IAC passageway through the throttle body. Make sure it's throttle body cleaner and not carburetor cleaner, the carb cleaner is to corrosive to the gaskets used on the throttle body.
If cleaning the IAC does not help, then it's a good chance that the IAC is to far gone and will need to be replaced.
Good luck and thank you for using fixya

There is a technical service bulletin that may apply to your problem the no. is 09-8-9

ISSUE: Some 2005-2009 Escape Hybrid and 2006-2009 Mariner Hybrid vehicles may exhibit an intermittent Red Triangle On and Stop Safely Now message displayed on the message center accompanied by a sudden RPM loss/no start symptom with a diagnostic trouble code (DTC) P1A0C. Vehicles may exhibit this symptom on the first start of the morning or after an extended idle. The symptom will clear on the next key cycle.
ACTION: Follow the Service Procedure steps to correct the condition.
SERVICE PROCEDURE For vehicles outside the new vehicle limited warranty, if diagnostics lead to replacing the throttle body you may use this procedure to clean the throttle body as an alternative to replacing it. This procedure is not covered by the new vehicle limited warranty. NOTE: THIS CLEANING PROCEDURE CAN ONLY BE USED ON NON-COATED THROTTLE BODIES. Refer to Workshop Manual, Section 303-04C Removal and Installation - Throttle Body.

1. Remove the throttle body.
2. With the throttle body positioned to the side, open the throttle plate.
3. Using Motorcraft® Choke and Linkage Cleaner or equivalent, spray the throttle body plate and bore.
4. Using a suitable (nylon) brush, clean the edges of the throttle plate and the mating surface of the throttle bore to remove all carbon build up.
5. Reapply Motorcraft® Choke and Linkage Cleaner or equivalent and wipe clean with a lint-free cloth.
6. Remove old throttle body gasket and discard. Install a new throttle body gasket.
7. Install the throttle body.

PART NUMBER PART NAME PM-14 Motorcraft® Choke and Linkage Cleaner

Buy it new from many places Search Saturn Parts call local Dealer .
Happy Easter

Yup. The throttle body connectors have a history of failing on these cars. Replace the throttle body and the wire connectors that go to it, and you're back in business. Not terribly difficult and you can get the parts from any dealer. Saturn actually has a bulletin out on this problem but they won't cover it unless you're under warranty - no recall for this.