The electric door lock on driver's side will not lock when car is put into gear or by using the keyfob - must do it manually

The alarm is armed if keyfob is used. So you must use the fob to disarm alarm first. So someone can not unlock and open door without keyfob or alarm will be set off.

Try pressing the unlock button twice

THAT IS NORMAL OPERATION. IT PREVENTS YOU LOCKING YOUR KEYS IN THE VEHICLE. GO GET A NEW WATCH BATTERY FOR THE REMOTE AT THE DRUGSTORE.

If the car goes "beep beep" when you try to lock the doors something is still open.
otherwise
Sounds like a defective keyfob try a new battery, try your spare if you have one.
If you don't have a spare you should get one anyway.
You can match your new keyfob to the car by following instructions here:= http://www.bluejag.co.uk/X-Type-keyfob-reprogramming.php

Sounds like the switch is bad. Try passenger side lock button or keyfob lock. If they work and not driver side, then it's the switch in the doorpanel. If none work to lock, but all will unlock, then it's probably the little lock motor inside driver door.

Replace the battery, and when the fob is open check the micro switch for pop, coffee contamination it may be sticking. and the key operation is normal,only the driver side gets open.

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Having the same problem with my 03. Couple things to try:

1. Remove the batteries one of your keyfobs when you park for the night. Make sure the doors are still unlocked. If it's not locked in the morning, you'll need a new battery or keyfob. If that doesn't work, test the other keyfob the next night.

2. If you're also having trouble getting the windows to go up, it might your master switch on the driver's door. But, if no trouble with the windows, I'd doubt this is the issue.

3. You can wiggle the wiring harness in the driver's side door to see if you can make the door lock that way. If so, you might have a loose connection. Nissan tried to tell me that the wiring harness needed to be replaced, but that didn't help.

Good luck!

check lock buttons on doors and keyfob for stuck button

I recently changed the batteries in the key of my 2001 Audi TT. To reprogram it, I needed to take this 1 key to the vehicle, click on the unlock button and within 1 minute, open the driver side door manually with the key. It worked.

Your key fob needs reprogramming, and yes the alarm will go off when you open the door, but you have enough time to put the key in the ignition which will prevent the alarm sounding. Car is usable until you get the fob sorted by locking and unlocking using the key.