My 2006 Saturn Doors won't lock from the remote but will UNlock from remote. The driver side door will not lock but will unlock using the button on the door. However, the passenger side door button will unlock and lock. What is causing the issue with the remote and driver side door?

https://www.autogenius.info/saturn-vue-2001-2004-fuse-box-diagram/
The fuse box diagram above says you have a drivers side relay and passenger side relay. If that is correct you might try change the two relay. If the passenger side does not work after that you know the relay is bad. If the two relay are the same. It also show a relay for all the doors.

https://www.2carpros.com/questions/saturn-ion-2004-saturn-ion-power-door-lock

2008 Saturn Vue liftgate will not open

The endgate/liftgate can be locked or unlocked by operating either one of the front door lock switches, your's doesn't do this ?
Endgate/Liftgate
Once the vehicle doors have been unlocked, the endgate/liftgate can be opened by using the handle mounted to the exterior of the gate. The endgate/liftgate can be locked or unlocked by operating either one of the front door lock switches, or by pressing the Lock/Unlock button on the key fob. The endgate/liftgate lock and unlock functions operate in conjunction with the rear doors.

Change the battery in the remote key.

Sounds like the drivers door lock switch is bad an as far as the auto start remote the contacts under the button get dirty and won't make contact, open the remote like changing the battery and you can probably get at the contact button, if it's a little carbon button they can be cleaned with a pencil eraser and then paper tower with a bit of rubbing alcohol, if it's an actual switch you can try spraying some contact cleaner into the switch. let it dry before you put the battery back in.

it is not the actuators, try a different remote, you may have an issue with the car security system/body computer not functioning on the unlock driver door command, one press of remote is unlock driver door and 2 presses is unlock the other doors.

this is a problem that can appear after your car battery died, cause the car didn't reset propely, so taking the battery out and putting it back in or letting your car die again would do the trick. I tried a lot of reprogramming procedured for my remote key, none of them worked, what did the trick though was simply unlocking the doors via the all door unlock button on the passenger side door, so simple.

have you checked the fuzes ?

both the rear passenger side wont unlock ???? How many doors are on the passenger side ? Or both back doors don't unlock ? Two relays lock / unlock the back door's Not the lift gate . The BCM controls the relay's . The relay's are located in the rear fuse box . Under back seat .

1. Close and lock all doors with the driver’s side power lock/unlock switch.

2. Insert key into ignition and remove it from the ignition key cylinder at least six times within 10 seconds. Your Hazard
Lamps will flash if you have performed this step successfully. NOTE: Withdraw key completely from ignition cylinder
each time. If this procedure is performed too fast, system will not enter programming mode.

3. Insert key into the ignition cylinder and turn to the ACC position.

4. Within 5 seconds, push ANY button on the remote transmitter. Your Hazard Lamps should flash. NOTE: Do not press
the button more than one time in the above step. If the button is pressed more than one time, the programming
procedure will not be successful.

5. If there are any remaining transmitters (including the old ones), unlock then lock all doors using the driver’s side
power lock/unlock switch and within 5 seconds, push ANY button on the next remote. Your Hazard Lamps should
flash. Repeat this step for each transmitter (including any existing transmitters).
6. Turn the key to the OFF position, remove keys from the ignition, unlock doors using the driver’s side power lock/unlock switch and open the driver side door.

hi did you sort this fault out i have the same problem