Excel running on a 32 bit PC and using a 32 bit operating system can only address 2 Gb of RAM. If your machine has a 64 bit processor (these were being shipped over 5 years ago) it will be possible to install a 64 bit operating system such as Windows XP 64 bit or Windows 7 64 bit. It has been claimed that an Excel 2010 spreadsheet, running on a 64 bit machine and using Windows 7 64 bit, was able to load and use a database with 100 million records.
If you are unable to do this then I suggest that you examine what your machine is running at the same time as your spreadsheet and if any part of the spreadsheet can be off-loaded. By the latter I mean can any of it transferred to another Excel file?
Are you using any links on your spreadsheet, if so can the links be converted into data, e.g. a link to a lookuptable could be converted to data (copy, paste-special, value) and this remove a significant amount of processing load.
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