Without seeing the file, it is difficult to diagnose what is going on, but I will offer some ideas.
What version of Excel are you using? Are you using Excel 2003? Was the file you are trying to open created in Excel 2007 or Excel 2010. If so, it might be using the new format and therefore will not open in Excel 2003 and older.
It is possible the Excel file is data that was imported from a source in which Excel cannot import. Does the Excel spreadsheet contain any imported data?
Try to use: XLSX Viewer Tool here :
http://www.xlsx.viewertool.com/
Those are the most likely causes of the corrupt data. Is every file you open in Excel corrupt, or just this one workbook? If it is just this one workbook, then, yes, it sounds like it is corrupted. If every file you open with Excel is corrupt, then your version of Excel could be corrupt, but that is unlikely.
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