Does the fender passport deluxe 500 differ from the fender passport 500 pro

SOURCE: What's the best way to connect a PC (with DJ

Best way is to use a 1/8 TRS (stereo) to 1/4 TRS (stereo) cable from the PC into the Stereo 1/4 inch jacks right below the RCA stereo input jacks.

TRS stands for tip-ring-sleeve which means the jacks have the extra "ring" over a mono jack.

SOURCE: Fender Passport 500 System Speaker showing 'red'.

Unless you abused the cable badly, this is UNLIKELY. More probable is failure of the amplifier.
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'The Speakon connectors are usually pretty reliable,

SOURCE: One of my Fender Passport

You have probably blown the speaker... swap left and right to verify it is the speaker... These speakers are NOT too well suited for bass... They typically have low impedance speakers in series. You run a risk of popping the amp running with a blown speaker. You MAY have to replace all the speakers in the defective cabinet. ALL the speakers must be identical. The Passport 250 uses four 2 ohm speakers in series... not sure about the 500. It may have two 8 ohm in parallel. Do not use the speaker until it is fixed... the amps are hard to repair if a defective speaker cooks them.