Targus Wireless Mouse AMW50US scroll direction jumps back and forth

your scroll wheel is most likely of track

Download and install from here:http://www.targus.com/us/download.aspx?regionid=&sku=AMW50US&PageName=&productCategoryId=

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The battery cover is the part of the top of the mouse on the opposite end from the scroll wheel. Turn the mouse upside down with the scroll wheel away from you. On the end closer to you is a latch (called a "hinge" in the user manual) for the battery cover. Depress the latch and slide the battery cover off of the end.

The user manual is at
TARGUS AMW1603EU User Manual

Here is Driver Link: AMW50US Driver Update (v4.1)
Here is Manual Link:
AMW50US User Guide

usually if you press down and back on the top of the mouse right behind the scroll wheel you can access the batteries

sure try getting latest drivers

1st mite have a virus or you need to redownload the driver for it try rebooting it .

if you're having issues with a "mighty mouse" let me tell you that no matter how well you clean it, the problem will continue. If you can't get a free replacement from Apple, the best experience for us at my office has been to move to Logitech bluetooth mice. Logitech V270 Cordless Optical Bluetooth Mouse works great and you have all the functions you need like scrolling, right and left click, etc.

This may not be a solution for you but at least it may explain the cause of the problem. I recently had the same problem - the scroll wheel suddenly began to go crazy, jumping all the way to the bottom or the top of a document, or randomly skipping around. The unit was still under warranty, and Microsoft sent me a new mouse. Since they did not require me to return the old mouse, I decided to take it apart to see if I could find the problem. I found poorly soldered electrical joints to the optical sensor & LED which convert the scroll wheel movement to electrical signals. After I resoldered these connections the mouse worked fine again.

did u download latest driver form website maker site dont use cd