Brand new out of the box Dell 560 set everything up and plugged in the speakers to the USB and the jack in the back and nothing no sound. the speakers are on, but the machine says no device detected. Plugged in headphones and they work fine. what is the issue?

If your computer came with a motherboard disc the sound drivers could be on it
click start control panel administrive tools computer management device manager scroll to sound,video and game controllers you might see a yellow question exclamation mark? ! or a red X Right click to reinstall drivers
click start control panel sounds and audio,volume,advanced,speakers make sure you have selected the
(((appropriate speakers))) also audio you will find 3 drop down lists make sure you have the correct settings there
also
click start control panel sounds and audio devices select advanced there might be a tick in the mute box untick it
if his does not fix the problem
click start control panel sounds and audio devices you can adjust the volume there also select speaker volume you can change your settings there you can also tick in the box place icon in taskbar for any further volume control settings you will need to right click on the volume icon system select adjust volume

click start control panel sounds and audio,volume,advanced,speakers select the appropriate speakers from the drop down list or navigate to the device manager scroll to system devices + to expand,system speaker right click properties then select use this device (enable) also you might check
the speakers plug/outlet is usually at the back of the computer you will have to open up the computer to check the lead attached to the rear of the input plug make sure the connection is good
try cleaning your computer of dust using a fine air blower from a compressor making VERY sure that there is no MOISTURE in the air line specifically around the sound card and the CPU central processing unit dust causes static to build up in a computer hope this helps