2000 Ford Tuarus 130K P0301 misfire on one. I changed Coil pack,Plugs, wires, fuel pump, fuel filter,PCV, all OEM. P0301 went away but then got a P0300 the next day. not sure what to do now.. need help. I cleared the P0300 code to see if it will come back. Also in park if i rev over 4000RPM it misses it that the rev limiter

Then you went to a shop that doesn't have the
skills necessary to resolve much,cylinder misfires
in your case

You never need a MIL Lamp, to check for codes,cylinder
misfires & other data

Have you run a compression check on that cylinder? Have you verified the fuel injector is working?

These codes are making me lean towards the ignition coil pack.My stepson's 2001 Sable 3.0 v6 had one cylinder misfiring(5-code P0305),which shares a coil with cylinder 1(code P0301).I diagnosed it by trading wire 1 and 5 at the coil,and the code changed to P0301.You have codes for the two cylinders on the same coil,so this is most likely it.(these codes would also trigger P0300(Multiple Misfires Detected) and P0316(Misfire Detected First 1000 Revs)).

P0301 - Cylinder 1 Misfire Detected.

Causes:
- Improper spark plug at cylinder #1
- Insufficient compression at cylinder #1
- Incorrect fuel pressure
- The injector circuit is open or shorted at cylinder #1
- Fuel injector #1 may be faulty
- Intake air leak

Solutions:
- Perform Injector Service
- Replaced Spark Plug #1
- Replaced Injector #1
- Replaced Ignition Coil #1

P0303 - Cylinder 3 Misfire Detected.
Follow info from P0301.

P0316 - Misfire Occurred In The First 1,000 Engine Revolutions.

Causes:
- Damaged CKP sensor.
- Ignition System.
- Fuel Injectors
- Running out of fuel
- Fuel Quality
- Base engine
- Damaged Powertrain Control Module

Solutions:
Usually the P0316 is combine with a P03XX codes. The P03XX code indicates in which cylinder the misfire occurred.

COULD BE DIRTY FUEL INJECTORS .LEAKING INTAKE MANIFOLD HAS A VACUUM LEAK.

Try changing spark plug wires and have the fuel pump checked out and check fuel filters and fuel line to see if that is your problem.

a multiple misfire code can relate to a fuel problem check filter pump pressure let me know alan wrench

Sounds like either a bad plug wire, or coil pack. This is about all that would cause the misfire.

You may need to change the coil pack(s) or modular. The modular is what the coil pack(s) mount to. I'm not familiar with that engine so you may have a 3 piece coil pack, or a 1 piece. (If it doesn't have a distributor). You may first try replacing the coil wire. There is a good chance that is loose, or bad. It could also be the coil itself. Try the coil wire and if it still acts up, then try the others. Also, when you changed the plugs, did you put new plug wires? When I do a tune up on my vehicles, I change the plugs, wires, distributor cap and rotor, (coil pack,modular), whichever is equipped, oil, oil filter, tranny fluid and filter with gasket, valve cover gaskets, oil pan gasket oil filter, and fuel filter. Try changing the fuel filter as well, as plugged or dirty fuel filters can cause stall outs. I hope this information helps. Thank you for choosing fixya.com for answers.

You are mis fireing on cyl 1 and 3 if you replaced plugs and wires and coil this is going to be a fuel injector issue or valve issue. See if you can swap the injectors with known good cyl. and see if it changes. Or have a shop do a fuel injector service on it to see if it helps. It may be to late for the fuel injector service.