OK, if you have a misfire at a high rate of speed and it is intermittent, I wouldn't worry about it unless it makes the engine lose power or affects gas mileage.
If you want the engine to work perfectly, however, I would find out which cylinder is missing, and correct the problem by replacing coil packs or what not until it doesn't do this anymore.
Also, a bad O2 sensor can cause a 'random' mix that may come and go over time.
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