My 2005 chevy silverado 5.3 liter is overheating. It runs at about 250 from 0-45. Once i get past 45 and get some airflow it cools right down. i though my thermostat was stuck but shouldnt it stay hot at all times if that was it? other than that the electric fans are working fine. Also my heater would go from hot to cool. Could it be anything other than my thermostat?

Question edited for clarity.

Cooler lines

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misfires are from coils and injectors
most likely injectors as they are subject to electronic failures and dirty fuel

How to fix the Chev power window door lock switch - YouTube

? 5:04
https://www.youtube.com/watch?v=XDKaDURD8Sc
Jul 13, 2013 - Uploaded by spelunkerd
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Has the engine light come on yet?

it mite be your radiator... need to flush it or change it

Powertrain choices encompass everything from a frugal 4.3-liter 195-horsepower V6 to a muscular 6.2-liter V8 with 403 hp. Most Chevy Silverados, however, will be fitted with either a 295-hp 4.8-liter V8 or a 315-hp 5.3-liter V8.------------------------------------------------------------------------------------
Renault CAN Clip

The primer should be on top of the fuel filter housing assembly..there is a small relief valve you will need to open and at the top of the fuel filter housing there will be a somewhat large domed button that you will need to push down until fuel comes out the relief...put the relief valve screw back in and your done

this sounds like low coolant level,or air in the system, you said the fans work they should cool it down just like the air flowing through it, this tells me the coolant flow is not good until higher rpms,try reving the motor and see if it cools down without movig if it does then its a flow problem maybe tstat not opening all the way or borken, the waterpump empeller rotted,or low coolant,i would also flush the system out if its not clean, ive seen a few of these that use dexcool coolant get pretty nasty from lack of coolant flushes, start by checking the level then a t- stat, hope this helps.

spark plug wrench and alot of patients with the very back ones hard to get to

with radio off. press the set button and hold it down. while holding down set button depress the seek up/down buttons depending on which way u want to go.