My 2000 expedition hesitates when my gas gets low in the tank

There are many things that can cause this. It could be a stretched or jumped timing chain, low fuel pressure, a bad TP sensor, a faulty MAP sensor, a bad MAF sensor, intake manifold gasket, internal engine damage, or a clogged catalytic converter. I would start with checking compression to rule out internal engine problems. If compression is good on all cylinders next check fuel pressure. If these 2 areas are ok, perform a backpressure test to rule out a restricted exhaust.

Sounds like the engine is starving for fuel. You might try changing the fuel filter. It also cold be water in your fuel tank. Try putting some dry gas in the tank.

yu might have water in your tank so yu need to drain your fuel ank completly and clean it up

First the problem is caused by a defective fuel level sending unit, that is located inside the gas tank, the gas tank must be removed to access the part for replacement. As to the how much fuel remains there is not way to know this.

check fuel pressure at the fuel rail. could be a weak fuel pump. fuel pump 35 - 40psi. and or you might have a bad coil pack or sparkplug

My guess would be dirty fuel tank. Possibly clogged fuel pump strainer.

It could consist of skipping, engine cutting off or hesitates from starting, idling . Bad gas gives numerous signs, the best way I have found to deal with this is, Buy a octane booster 104, go to the gas station and put a couple of gallons of high premium in to tank to disperse the water in the gas. They also make a liquid to take water out of gas which also goes into the tank.

Running it that low may have pluged up the fuel filter from the sedament from the bottom of the tank. Try a new fuel filter.

add a can of SEAFOAM to 1/2 tank or more of gas. It will clean valves clean out water and goop from ethanol gas. then add every 3-5000 miles to keep the parts well.

If the fuel gauge drops off when you are driving then its a sending unit problem that means you have to drop the tank and replace the float and sending unit. This is a common problem for alot of cars because of cheap gas. If you have to drop the tank check the fuel pump canster for dirt because of cheap gas. Replace the fuel pump strainer and fuel pump filter. If the car or truck has about 100,000 miles you might want to change the fuel pump at that time also just to cover your back. If you take it to a shop they will charge you at least $900 to start. But if you do it yourself it will cost you about $200 dollars maybe alittle more.