My Lexus RX300 2000 model seat belt dinger comes on intermittently while I am driving. How can I disconnect this or eliminate it/

There is no dinger as the other guy suggests . sound comes from the driver door speaker .
The audible warnings alert the driver of a system concern or a critical vehicle condition. The radio generates the audible warnings through the left front speaker. The radio receives audible warning requests via the class 2 serial data line. If the radio receives multiple audible warning requests, the warning with the highest priority sounds first. On vehicles with an audio amplifier, the amplifier instead of the radio generates the audible warnings and receives audible warnings requests via the class 2 serial data line. Either the radio or the audio amplifier is the chime producer. The following lists the audible warning priority and the pulse rate:
Fast rate chime (150 pulses per min)
Medium rate chime (100 pulses per min)
Slow rate chime (50 pulses per min)
Turn signal reminder (will pulse at turn signal flasher rate)

Your best bet ,wear your seatbelt . so the sound goes off . If you do wear the seat belt and the chime sounds ,have a qualified repair shop check it .

What year.

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Does it ding with the seat belt latched ? if so you probably need a Multifunction Alarm Module or have a shorted wire . Was the vehicle in an accident ?

Check for SRS System codes,diagnose them
& make the required repairs

Pull your seat belts out a couple times & keep using it,
may go out

There is a sensor under the seat it is faulty simple fix is up plug the beeper under the dash until you can get it replaced it is on the drivers side under the dash easy to find open the door and it will take you to it just pull it out and keep it until you get a new sensor will not hurt anything and just were your seat belt if you cant rember to buckle up write on your window Buckle your seat belt You will be ok

look 4 a bad wire on seat belt its not making contact someware and beeps like its not hooked up

sorry this code is not showing in the toyota OBDII readout,no listing for lexus but i would imagine its the same as the parent company ,try disconnecting the battery then clean the connections under the seat on the plug and on the pyrotechnics on the bottom of the seat belt and see what happens ,Most manufacturers use encrypted software here on airbag systems so its a dealer only job iam afraid and hope you have a deep pocket.If they want silly money and give the usual dealer expensive type job then disconnect the light from the socket then reconnect to a glow plug relay so light comes on for 10 secs then goes off .mount relay in teh boot so they dont here it clicking for the inspection

Removal should be very straight forward, there should be a detachable wiring harness as well as seat bracket bolts on all 4 corners ,hopefully the bolts are not rusted.
However if you do remove the seat and reinstall it, it is possible you will need to re initialize the power seat settings as the dealer might have done when the car was new.
This is part of the PDI process when a car is bought new, bought not required on all models..... While I have not seen it done on an older RX it generally involves running the seat full span front to back in it's track and going through a range of motion functions for height, etc. Be careful to check for proper torque specs in the seat bolts as well as it and it's belt are safety features

well you could cut the dinger out.. but I would not recommend doing that. Usually it makes more sense to just wear your seat belt as local laws require