The drivers side door lock will not actuate with the remote or the interior switch. The key will open and close the door. All other door locks function properly with remote and interior switch.

Opening the door with the key should turn the alarm off. It is the certified way to get into a car if the key fob remote fails. Get a local auto locksmith to get you a new fob and key and program it. Keep the old one as a spare key.

Remove inner door latch and try operating the rod manually (vice grips). If locked, spray everything inside the door with WD-40 or the like and try operating the lock.

The locks on your vehicle are electronically controlled by the BCM - body control module . The driver an passenger door switche's are input's to the BCM . Do you know anything about automotive electronic's ? anti theft alarm remote, could this be part of the problem , No it's just a key less entry remote , nothing to do with the anti-theft .
Door Lock System Components
The Power Door Lock System consists of the following components:
• Body control module (BCM)
• Driver door lock switch
• Front passenger door lock switch
• Door lock actuators in each of the doors
• IBCM (PWR) 15-amp fuse

Door Lock System Controls
The Power Door Lock System is controlled by the body control module (BCM) and can be activated by any one of the following:
• A door lock switch Lock or Unlock actuation
• A keyless entry transmitter actuation
• An automatic door lock actuation
• An automatic door unlock actuation
• A last door closed locking (LDCL) actuation

Driver and Passenger Door Unlock Operation w/o Keyless Entry
When the body control module (BCM) detects a transition of either of the door lock switches to the Unlock position, it switches the door lock actuator unlock control circuits to voltage. Since the door lock actuator lock control circuit is at ground potential within the BCM, the driver passenger door lock actuators transition to the Unlock position.

Your best bet , take your vehicle to a qualified repair shop ! Need special tool to diagnose .

Power Door Locks Inoperative

Install a scan tool.
Turn ON the ignition, with the engine OFF.
With a scan tool, observe the door lock switch parameter in the Doors data list.
Does the scan tool display Idle?
YES - Go to Step 4
NO - Go to Step 8
4
Activate the driver door lock switch to the LOCK and UNLOCK positions.
Does the scan tool display Idle?
YES - Go to Step 9
NO - Go to Step 5
5
Activate the front passenger door lock switch to the LOCK and UNLOCK positions.
Does the scan tool display Idle?
YES - Go to Step 9
NO - Go to Step 6
6
With a scan tool, observe the driver door lock actuator command and the passenger door lock actuator command parameters in the Doors data list.
Activate a door lock switch to the LOCK and UNLOCK positions.

That sounds like a seized linkage issue. Open door panel and disconnect linkage from the actuator. If the actuator works, it's the linkage

Replace the driver side door actuator.

If you need further help, I’m available over the phone at https://www.6ya.com/expert/flavio_517b938f50183b92

shorted wiring in doors or shorted door lock actuator in door. A grounding of a wire makes them lock normally. SO, any bare wire touching metal will ground it and lock the doors.

Principles of Operations
The Door Switch Lock Function When a door lock switch is moved into the lock position or a door lock cylinder is rotated to the lock position, the door lock switch grounds the lock circuit input to the central security module (CSM). The CSM then provides 12 volts to one side of the door lock actuators contained in the door latch unit and simultaneously grounds the other side of the door lock actuators. This completes the door lock actuator circuit, causing the door lock actuators to rotate a cam assembly, which then locks the doors. The 12 volts that the CSM provides to the door lock actuators are provided to both door lock actuators from a single pin on the CSM electrical connector.
The Door Switch Unlock Function When a door lock switch is moved into the unlock position, the door lock switch grounds the unlock circuit input to the CSM. The CSM then provides 12 volts to the opposite side (relative to locking the door) of the door lock actuator(s) contained in the door latch unit and simultaneously grounds the other side of the door lock actuator(s). This completes the door lock actuator circuit, causing the door lock actuator(s) to rotate a cam assembly in the opposite direction, which the unlocks the door(s). The 12 volts which the CSM provides to the door lock actuator(s) are provided to each door lock actuator from the individual pins on the CSM electrical connector.
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CSM Self-Test The CSM has a self-test which can be entered into by using a diagnostic tool. This self-test will monitor the following CSM door lock inputs:

• Unlock switch (DTC B1311)
• Lock switch (DTC B1300)
• Exterior lock switch (DTC B1309)
• Exterior unlock switch (DTC B1341)

Before running the self-test, the following conditions must be met:

• The ignition switch must be in position II
• The driver and passenger doors must be unlocked
• The driver and passenger doors must be opened
• The hood and liftgate must be closed
• The set/reset switch, and liftgate release switch are not actuated

It is important to note that all of the diagnostic trouble codes (DTCs), with the exception of B1551 and B1553 can be retrieved with the self-test. DTCs B1551, and B1553 are continuous and will only be retrieved if the liftgate release is operated prior to retrieving the continuous DTCs.
Inspection and Verification

1. NOTE: Make sure that the battery is fully charged before starting electrical diagnosis.
   NOTE: Prior to carrying out the CSM Self-Test, make sure that both the driver and passenger doors are open.
   Verify the customer concern.

1. Visually inspect for obvious signs of mechanical and electrical damage.

Visual Inspection Chart Mechanical Electrical

• Binding latch mechanisms
• Binding linkage
• Misaligned door

• Central junction box (CJB) fuse(s)
• Wiring harness
• Electrical connector(s)
• Door lock switch(es)
• Door lock actuator(s)

Module Controlled Functions
The central security module (CSM) covers the following functions:

• Central door locking
• Double door locking
• Anti - theft alarm incorporating
  • forced entry
  • radio theft
• Radio frequency remote control of
  • central door locking
  • panic alarm
  • driver door unlock
  • liftgate unlock

For additional information, refer to Section 419-01A Anti - Theft - Active, Section 501-14A Handles, Locks, Latches and Mechanisms, and Section 501-14B Keyless Entry/Computer Operated Locks.

The CSM is in the passenger side kick panel I think.

Good luck

-If the problem is that keyless remote does unlock or lock door, but the lock lever still move when pulling up and down by hand. Door still open and close with both inner and outer, then might the driver door lock actuator is bad. The actuator lock and unlock the door for you when using the keyless remote or door lock/unlock switch.

-if you try using the key to unlock door and the key doesn't turn the door cylinder, then you have a bad door lock cylinder.

-if the lock lever doesn't move up or down and you can't open door using any handle, then you got a bad lock latch assembly.

I'm not sure what the issue is but hope this helps you.

renew the drivers door lock or check if the operating solonoid is seperate from lock if so then often a good drop of engine oil down the operating arm often works

The horn chirp can be disable by pressing the lock and unlock buttons simultaneously until the hazard lights flash, and no enable press the lock and unlock until the horn chirp.
To reprogram (enter new ID) key fob (keyless remote controller) follow the steps.
1. Close all doors and lock all doors
2. Insert and remove the key from the ignition key cylinder more than six times within 10 seconds. (The hazard warning lamp will then flash.) NOTE: Key should be withdrawn from ignition key cylinder completely each time.
NOTE: Do not rush the insertion/removal key cycling process. The side marker/tail/license lamps and interior illumination will flash twice when this step is accurately completed.
3. Insert key on ignition key cylinder and turn ignition key switch to "AAC" position At this time, the new ID code is entered and original (previous) ID codes are erase.
4. Press any button on the new remote controller once. (The hazard warning lamp will then flash)
NOTE: Do not press the button more than one time in the above step. If the button is pressed more than one time, the programming procedure will not be successful. The side marker/tail/license lamps and interior illumination will flash twice when this step is accurately completed and programming is successful.
If there is only one remote controller skip step 5.
5. Additional ID code entry Release the door lock, then lock again with door lock/unlock switch (In power window main switch)
6. Remove key from ignition
7. Unlock driver side door, open driver side door and then close the door. (END)

if you turn the key twice it should unlock and lock all doors until you can figure out the remote/lock switch problem.sounds like a door lock actuator problem on drivers door.I would start there.