I have a 2005 grand caravan v6 3.3L cylinder 5

if you cleared the code - fixed arc and checked their are no more arcs - and keeps coming back then problem can be a burnt or carboned valve --lifter -push rod --piston

Cylinder 5 misfiring.
I have heard, plugs, wires, coil, and a few other less obvious cures. If the engine is 10 years old and plugs and wires have never been changed, they are overdue. Fouled rear plugs can be caused by old stiff wires not conducting as they should, which will cause the rear plugs to further degrade and cause the coil to overwork resulting in lower output, which some people overcome temporarily by gapping their plugs a little closer and a myriad of other temporary measures, The next logical check would be compression,

2005 Dodge Grand Caravan 3.8L engine misfire on cylinder 5.

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Aug 14, 2012 - MIL on; cylinder 5 misfire; most noticeable at idle in gear ... This could be caused by an EGR valve that is sticking partly open and not closing ...

OBD-II Trouble Code: P0305 Cylinder 5 Five Misfire Detected

www.obd-codes.com/p0305

A P0305 code means that the the car's computer has detected that one of the engine'scylinders is not firing properly. In this case it's cylinder #5.

ODB Code P0305- Misfire in #5 Cylinder - 2008 Dodge ...

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Feb 22, 2011 - ... do something with a misfire in the #5 cylinder of my V6 4.0L engine. ... ODB Code P0305- Misfire in #5 Cylinder on 2008 Dodge Grand Caravan .... My2005 dodge grand caravan jerks when it shifts into gear what could it be.

My Dodge Grand Caravan has a Cylinder 5 Misfire,? ' Yahoo An

I have run into these caravans burning oil, not much you can do except keep an eye on the oil level or spend a lot of money having piston rings replaced.
The best way to go about finding the misfire would be to go to an auto zone or other auto parts store that will scan the computer for codes. the codes will tell you which cylinder is misfiring.
I would bet it could be a fouled spark plug due to oil burning but could be a plug wire also.Have the codes read and find the cylinder that is misfiring and remove the spark plug and see if the tip is covered or worn down, if it is then replace spark plug and you may want to do them all. up to you.
If the plug is okay then move on to spark plug wires, swap the misfiring cylinder wire with another cylinder and see if misfire moves if it does then replace the wires.

To find the cylinder by #. If you are standing if front of the van looking at engine cylinders 2,4,and 6 are in front, closest to radiator from left to right. then cylinders 1,3,and 5 are at the rear also going left to right.
Good day.

did you check the coil it may be bad. for # 1 cylinder. if you can, just replace them all. then you will know everything is ok! but change #1 coil first to find out. try putting some injector cleaner in the tank, or swapping the injector from the #1 cylinder to the #2 and see if the code follows it and let us know.

Dirty fuel injectors. Computer will show misfire on the cylinders that are malfunctioning. If injector cleaner in tank won't clean them, pull them all out and have a professional take them apart and cleaned. Each injector has a screen in it that can get plugged up. Think about Bro, all other stuff has been renewed.

Try this firing order sequence and see if everything is as seen here.
Firing Order:
1-2-3-4-5-6

Cylinders:
........(back).......
'...1....3....5...'
______________
'...2....4....6...'

Ignition Coil:
.......(back)
.....connection
...........'
..........V
5........1........3
2........4........6
.......(front)

if the problem didn,t exist before you done this then you have the firing order off or have damaged one or more of the plugs

2005 CARAVAN 3.3L.
Van misfires, code says coil three . change out with new a cam sensor , injector, wires , plugs and of coarse coil. What is left and why would the pcm just have a problem with # 3.
ps i checked the compression and all six cylinders have 165. lbs.

p0456--emission control system leak(verysmall) leak, check all hoses to emission controls, cylinder 3 missfire detected. could be plugs, wires, or coil.this is code p0303,