2005 lexus es 330 vsc and check engine lights on what is wrong with it ?

any parts store will read / get codes for free...

Hello, the reason for the vsc light to turn on is that the check engine light came on first causing the vsc system to become disabled, this is normal, once the cause of the check engine light is fixed the other lights will turn off. You'll need to find out the diagnostic codes that caused the check engine light to turn on first, most auto parts stores like autozone, pep boys, o reilly can help you with getting those codes from the computer and they do this for free in most US states, when you have the code numbers you can reply if necessary and I can advise as to what should be done.

take it to a autoparts store neer you and they will tell you the problem and they will reset you computer

disconect the batery ground for 30 minutes and it will reset the computer

Read my GX post from today... same issue, loose gas cap or fouled sensors 95% of the time....

Often caused by a loose gas cap or fouled or failed air fuel O2 sensor. Check your gas cap is fully ratcheted, Drive a day or two. If lights don't clear you will need a code reader attached to the car to diagnose.

VSC is Vehicle Stability Control. This is and electronic sensing which monitors and combines performance of braking, wheel slippage and handling, ect.
If this light comes on along with check engine light, it can be caused by a loose gas cap or faulty o2 sensor.

if not a loose gas cap then what might be the problem

need to scan computer before you do anything else.

Basically, stop driving it until you can get the transmission serviced.
If you can safely jack up the vehicle and support it so it cannot fall on you, you can possible save some money by checking all the electrical connections to the transmission. Sometimes the problem is a loose or bad connection. If that does not work, your safest bet is to bring it to a certified mechanic, especially one who specializes in Lexus.