Do you have Norton Security? It could be blocking it.
Uninstall Norton and try AVG antivirus. Norton is a horrible program, I've had bad experiences.
Or disable any antivirus or firewall you have and try running iTunes.
Or try this.
1. Go to Control Panel --> Add or Remove Programs --> iTunes --> Remove
...uninstall the program completely and restart your computer
2. Go to Control Panel --> Add or Remove Programs --> QuickTime --> Remove
...uninstall the program completely and restart your computer
3. Go to My Computer --> Local Disc --> Program Files. Once in Program Files you will see the iTunes and QuickTime folder and you will want to delete the iTunes folder and the QuickTime folder. Right click on the iTunes folder and select delete and confirm the deletion. Do the same for QuickTime.
4. Restart your computer
5. Disable all features of any anti-virus program such as Norton or McAfee
6. Open Internet Explorer or which ever internet program you use and go to http://www.apple.com/itunes/download/ and download the iTunes+QuickTime program. *Do not do any modifications in the download of the program.* Just download the program by doing the usual "Next" clicking.
7. Once iTunes is finished downloading, double click on the Shortcut Icon on the desktop. iTunes should open with a large square box and you have to click "Agree."
Should be good to go.
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