Http://www.shopping.hp.com/webapp/shopping/supplies_model.do?product_code=CC210A&jumpid=oc_R1002_USENC-002_HP%20Photosmart%20C4280%20All-in-One%20Printer&lang=en&cc=us
The 350XL cartridge is not listed on the website for your c4280 printer.
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