Hi, I think its compatible with Dell Inspiron as long as the 320GB uses the same cable like IDE or SATA with that dell inspiron, and I think if ever your machine right now uses on the IDE cable it can still handel a 320GB capacity because an IDE cable can accomodate up to 500GB size Harddrive. Also I would suggest that if this would work on your machine try partioning your 320GB to one 60GB for your operating system and the other space is for your data storage. Hope this helps
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