As the Wii uses discs that can be scratched, dirty, or otherwise damaged -- it's important to first check the disc.
Look for fingerprints or other smudge marks. If you have dirty marks on the disc, you can wash it off with regular dish soap and water. Not too much soap though. Make sure you dry it off with something very soft [like a microfiber cloth] before you put it back into your Wii.
Second -- scratches will stop a disc from playing... or the disc will play until it gets to the scrached section then give you an error. Check and make sure there are not too many -- or deep scraches.
If a scratched game won't play through but other games play just fine -- chances are the disc is bad. However, if nothing is playing through on your Wii, not even a new game, there is a problem with the Wii's DVD drive. There is a laser in the drive that reads discs -- and many other moving parts in there. The following website sells the Wii DVD drives. It's not too difficult to replace yourself:
http://store.richspsxparts.com/wiiredvddr.html
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