Well first start by verifying USB port works by plugging in a hard drive or something thus proving you have a good port and USB Cable. At which point hook the keyboard up ( and make sure to properly install drivers provided on cd with purchase) being a pc this may take several attempts to install. What software are you trying to control? Reason? Logic? Fruityloops?
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Does the USB power the controller up? In those programs is there a way to search under preferences/midi for a controller input? Try alsohttp://www.alesis.com/q49?tt=5
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