I think I follow what your asking, so I'll do my best.
It reads that you want to play a movie you have on a flash drive through a digital picture frame.
Have you tried copying the flash drive to the internal storage and them playing the movie?
I think the biggest part of the problem is that the picture frames aren't capable of playing full movies, just slide shows. And any sound it has is on a separate section; not truly "linked" like a DVD or computer is. Picture frames are pretty much one trick ponies.
pluging in a usb cable from a computer that allready has the device driver loaded , should send the photo frame into accept mode automaticly , then its all done via the connected computer , nothing on photo screen should matter , till usb cable is disconnected , sorry you cant leave cable connected .