Misfire could be a number of things:
a) spark plugs - change them if used over 15K miles - inspect/regap.
b) spark plug wires - change them if over 15K miles - inspect
c) ECM (electronic control module) - test with HEI (high energy ignition) tester.
The vibrating tells me that the engine is running on less than its normal
compliment of cylinders - the shaking is produced by the imbalance
caused in the engine by one (or more) cylinder(s)
not firing at all.
The "Check Engine" light probably is coming on due the the misfire condition. Go to Pep Boys or
Advance Auto Pats, where they'll tell you (free) your codes causing the "Check Engine' light to be
lit - the code coming from your truck's computer will probably be one or more of:
P0300 - Random/Multiple Cylinder misfire detected
P0301 - Cylinder 1 misfire detected
P0302 - Cylinder 2 misfire detected
P0303 - Cylinder 3 misfire detected
P0304 - Cylinder 4 misfire detected
P0305 - Cylinder 5 misfire detected
P0306 - Cylinder 6 misfire detected
P0307 - Cylinder 7 misfire detected
P0308 - Cylinder 8 misfire detected
P0313 - Misfire detected with low fuel
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