My power door locks and windows do not work on my 2006 Gmc sierra. could it be a fuse. Also the onboard computer was telling me the drivers side door was not shut when it was. Now I do not get any info from the computer.

Power windows don't use fuse's , has circuit breakers
• PWR WDO CB 25A (fuse block) (System power for left and right windows 2-door vehicles. System power for LF and LR windows 4-door vehicles)
• PWR WDO CB 25A (IP wiring harness junction block) (System power for RF and RR windows 4-door vehicles)

Door Lock System Components
The power door lock system consists of the following components:
• The driver door module (DDM)
• The passenger door module (PDM)
• The body control module (BCM)
• The driver information center (DIC)
• The rear door lock switch
• The door lock relay
• The door unlock relay
• The liftgate lock relay--utility vehicles with liftgate only
• The reversible door lock actuators in each of the doors and liftgate
• LOCKS 20A fuse (rear lock/unlock relay supply voltage)
• ECC 10A fuse (liftgate lock relay supply voltage)

Fuses? Frayed wiring?

the leakage inside the door lock maybe damage or deslocate try to check

The most likely culprit is your driver's door control module... it's built into the driver's window switches. Double-check all your fuses before replacing any parts.

The power window switch is actually a drivers door module. They are common for going bad. You have a bad one.

it is likely a relay in the fuse panel under the dash. feel the tops of them as you have someone try the power locks or windows if that is not working. the relay should click or become very hot.

the main switch is wore out, Had the same problem the dealer install new switch 100 dollars for the part 125 for labor good luck

I had the same problem in my wife's 2003 Yukon Denali. The power seats and passengers side window wouldn't work. Turned out to be a blown Buss Type fuse in the Underhood Fuse Block. It is the one marked MBEC 1 50amp. Hard to tell if the are blown so look very carefully. Should look like a hoop with two shiny solderlooking bubbles on either side. On my blown fuse, it caught my attention because it looked like the solder was missing and I had to look very closely to see the bottom of the "hoop" was open. They are very hard to remove and must be pulled straight up.
This type of fuse looks like a red square with a clear plastic top showing the fuse link under the plastic. On my vehicle it is on the top row second one from the left.

Check internal wiring harness inside the actual door, test the wire leads to each actuator and make sure they are getting power, I'd be willing to bet they aren't, for whatever reason