MY MOM HAS A 2000 MERCEDES BENZ S500 EVERY YEAR WE HAVE TO REPLACE THE BATTERY. NOW THE AIRTRAN IS INOP AND LOW TO THE GROUND JUST BROUGHT A NEW BATTERY AND CARE IS DEAD AGAIN!!!!

It looks like this should help:

Where is the relay for airmatic suspention pump on 2000 Mercedes S500

If pulling that out and putting it back in doesn't help, here's some more troubleshooting info:

2000 S500 airmatic problem Mercedes Forum Mercedes Benz Enthusiast Forums

does the front bumper need to come off in order to replace head light assembly on 2003 s500?

possibly flat battery in your car open the boot by key blade and jump the battery when you jup the battery be careful don't mix up the connection

seems like your car had flat battery open the boot by key blade and jump the battery or connect battery charger in it when you do that be careful don't mix up the connection.

Well try changing the battery and see if that helps your situation, if not then id start with a full tune up and go from there. Im sure a new fuel filter wouldent hurt either.

Slide catch on top of key to remove emergency key
Use this or small screwdriver to prise off top cover of key to see battery

It's not that unusual for a battery to fail that soon, and the "no lights, no nothing" says that it's the battery again. Your best bet at this point is to pull the battery and take it to the point of purchase for testing. They should either replace it under warranty or charge it for you. After you replace the battery you should have the charging/electrical system checked for possible shorts or power drains.
BillB

REMOTE KEYLESS ENTRY BATTERY IS WEAK OR DEAD.YOU HAVE TO LET DEALERSHIP REPLACE KEYLESS ENTRY AND REPROGRAM IT TO UNLOCK OR LOCK DOORS.

If you have a owners manual then the method is described there.

I had the s500 2001... so u have to take the steel emergency key off then introduce it obliqually and push it will open! ...not easy to explain better but any mercedes service can help u easily and quickly!