We have a misfire on number one cylinder we have replaced plugs and number one coil still running ruff. what should we try next?

Could be bad coil or module.

change all plugs with proper ones - they are picky for some reason - do not change number or brand from original - coils were probably ok, - get some injector cleaner and run through it but check for exhaust leak at e g r tube - is a common over looked cause of misfire - a thing to keep in mind is misfire isn't always spark issue. hope I was of some help

sounds like you might need to do a compression test. did you check to see if the code was the same? if you keep running it like that it can clog you catalytic converter. Might have a bad injector also.

Probably a head gasket problem,once again. It's burning the coolant off the plug . To make sure ,use a "block tester" from NAPA ,it is a liquid that changes color with the presence of exhaust gas in the coolant.

Sounds like you got blowen Head Gasket!!!

Hello, this engine has 3 ignition coils on the passenger side cylinder head, each coil fires two spark plugs, the spark plugs on thew other side have plug wires connected to one of the coils on the other side, the #6 cylinder wire connects to the #3 coil, try replacing the spark plug wires

saturn had a lot of problems with the coil posts getting rusty that will cause the misfire on cylinder number 3 and any skip will cause the random misfire see as one coil fire two cylinders the egr sensor is built into the vavle and try stick closed from carbon build up cleaning it will only putoff replacing it if it operates at all

A multi misfire may mean that one or more of the following has happened:
Faulty spark plug or wires, Faulty coil (pack), Faulty oxygen sensor(s), Faulty fuel injector(s), Stuck/blocked EGR valve / passages, Faulty camshaft position sensor, Defective computer.

The engine is stumbling or hesitating, check all wiring and connectors that lead to the cylinders (i.e. spark plugs). Depending on how long the ignition components have been in the car, it may be a good idea to replace them as part of your regular maintenance schedule. I would suggest spark plugs, spark plug wire, distributor cap, and rotor (if applicable). Otherwise, check the coils (a.k.a. coil packs). In some cases, the the problems were faulty fuel injectors. 

Random misfires that jump around from one cylinder to another (read: P030x codes) also will set a P0300 code. The underlying cause is often a lean fuel condition, which may be due to a vacuum leak in the intake manifold or unmetered air getting past the airflow sensor, or an EGR valve that is stuck open.

Good luck and hope this information helps, keep me posted, be glad to help you get the truck running 100% again. Not sure if your running a K&N air filter, and if you are there may be a flim of oil on the MAF sensor that is making you run lean. You may want to spray down the MAF sensor with a can of MAF cleaner. 

misfire caused by leaking in the intake valve you must chek it , or may be your car is working rich that means fuel - air mixture is not on the right ratio so check your oxygen sensor

might be the coil pack is bad, wires, plugs, o2 sensors, dirty injectors, catalic converter ( only if you smell rotten eggs ) . cylinders are misfireing.