My 2000 durango won't shift into drive. - 2000 Dodge Durango

Look under your truck and see if the shift lever is connected to the transfer case.
Quite often the cotter pin that holds that together comes out, if that's the case just put a new one in and it will engage and stay engaged.

Your best bet for shifting Dodges are in neutral.

By run - do you mean it dies when you put it in gear? Or that it just bogs down when you attempt to accelerate or drive away?
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A plugged Catalytic converter will cause this. So will a Bad MAP or MAS (Mas Air ) sensor. So will a bad TPS (Throttle Position) sensor.
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Need more input to answer more precisely.

It's the Hub Bearing.

with it running place it in neutral , now either turn on or shift it into either 4wd high or 4wd low.. shift the tranny into reverse and roll back approx 5-10 ft you should be able to hear the hubs lock ..now your ready for the mud..have fun

I THINK THERES A POSSIBLE CHANCE THIS GUY MAY BE YANKING U AND YOUR FAMILY AROUND. I WOULD DEFINITELY GET A SECOND OPINION FROM A REPITABLE MECHANIC

I will try to help..ihave a 2000 dodge durango with the 4.7 v8..My trans started shifting funny and the rpm's would go up to 2000+rpm when i was driving, which means i was getting really crappy gas mileage at 40mph..took it to shop, engine light on,put it on machine to diagnose..got a generic p0700 code plus a couple others..code basically says tranny is fn up..
Try this a cheap fix first that worked for me..on the transmission,driver side there are two sensors..input/output transmission speed sensors..to be exact..they send info to computer to regulate shift points in trans..upshift and downshift..replace them both although one may be the culprit..cost at the dealer here in Delaware was $40.72 for one..there is one bolt(8mm)and one electrical connection to each..time to replace both about 15minutes you don't even have to jack up truck but you will have to get underneath.

Hope this helps and good luck..if you change them and find the tranny shifting properly..cycling the on and off switch will eventually turn off the engine light..just drive it normally i mean..go here shut it off..get back in start it up and go..it will go out..good luck

Govenor pressure solenoid and transducer fix alot of these.

the shifter cable has broke and the cable cost about $40.00

My Durango did the same exact thing. It would seem it was shifting from o/d to third constantly while driving down the road. As it turns out, it was the throttle position sensor. This may or may not solve your problem, but is a good place to start.