Can't get my 2005 ford f150 out of 2wheel low

Is the system ESOF ( Electronic Shift On the Fly ) or MSOF ( Mechanical Shift On the Fly ) ? When you engaged 4L, did you follow the procedure in the owners manual ? Did you happen to drive too fast with it. You should only have to put the trans in neutral or park to disengage it, some will still do the old school, back up a bit then put into park, and then try to disengage from 4L to 2H.