Check engine light on popped up code po 449. evap soelinoid vent clogged. I hear a clicking noise when i accelerate. are these problems in any way associated with each other?

The codes only tell the mechanic what to test, not what to replace.
You would need to get the shop manual for your vehicle to have the test instructions for each code.
Code 452 is a problem with the fuel tank pressure sensor circuit, 443 is evap canister purge and 449 is the vent valve circuit.
The evap system and those components would need to be checked out.

Google the location & a picture & replace yourself

Has to be near the fuel tank

PO449 is the Evap Vent Solenoid

PO 300 is random cylinder misfires maybe from the
extra air, when the evap purge runs

vent valve,check fuse,could be dirty.

PO 443--Evap Purge Control Valve Circuit

PO 449---Same thing---Vent Valve/Solenoid
Circuit Malfunction

DTC P0449 - Evaporative Emission Control System Vent Valve/ Solenoid Circuit Malfunction
The most likely problem is the evap vent solenoid which is mounted under the truck back by the fuel tank. The code is related to the circuit to the solenoid. Most likely the solenoid is shorted or Open which is causing the code to set. The other things to check if the solenoid is not the problem is the wiring to the solenoid could be corroded or broken or damaged. The last thing to suspect is the pcm which is the computer that runs the system. It could have a faulty driver inside, but I would suspect the solenoid or wiring first.

There is a bulletin for the vent solenoids getting dirt or road debris inside of them so when you go to get your solenoid, you may get a kit that will require you to relocate the solenoid and add a section of heater hose and a new inlet which you will need to mount around the passenger side of the trans. This keeps road debris and dirt from getting into the solenoid.

Check Diagnostis Information Procedure.

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this is an obd2 trouble code table, it can help you understand the meaning of code.
for the p0445, the causes:
A loose or improperly affixed gas cap
A non-conforming gas cap (i.e. not factory/original brand)
Other leak or damaged piece in EVAP system
Possible Solutions:
Remove and reinstall the gas cap, clear the codes, and drive for a day and see if the codes come back.
Otherwise, replace the gas cap, and/or
Inspect the EVAP system for cuts/holes in tubes/hoses (you may hear a vacuum noise or smell fuel), repair if necessary.
I know this tool can help you clear the code.

NOPE CANT ERASE CODES UNTIL THE PROBLEM IS FIXED OR THE SERVICE ENGINE LIGHT SOON WILL STAY ON. CODE PO441 - EVAPORATIVE EMISSION EVAP SYSTEM INCORRECT FLOW DETECTED.CHECK INTAKE VACUUM HOSE CONNECTIONS AT THE EVAP CANISTER PURGE VALVE.IF ALL IS GOOD.THE EVAP CANISTER PURGE VALVE COULD BE BAD. CODE PO 442 - EVAPORATIVE EMISSION EVAP SYSTEM SMALL LEAK DETECTED. EVAPORATIVE EMISSION SYSTEM LARGE LEAK DETECTED FUEL CAP LOOSE OR OFF MISSING. CODE PO 446 - EVAPORATIVE EMISSION EVAP SYSTEM VENT CONTROL CIRCUIT MALFUNCTION.

CODE PO449 EVAP VENT SOLENOID CONTROL CIRCUIT MALFUNCTION CONDITIONS. CHECK FUSE IF GOOD THE VENT SOLENOID FAILED.EVAP LOCATED ON A BRACKET NEAR THE FUEL TANK.

Your code means:

P0446 EVAP Canister Purge Vent Blocked

Some of the possible causes:

EVAP vent fresh air hose is clogged, kinked or restricted
EVAP Vent solenoid is contaminated, damaged or has failed
FTP sensor is out-of-calibration, damaged or "skewed"
PCM has failed

All tough thing for a lay person to check. You don't have to take it to the dealer, any repair garage that has the proper equipment can fix this for you.

it should be mounted on the charcoal canister near the fuel tank