Drivers door will not open from the inside or the outside, how do i get the panel off

You will need to remove the inside door panel, what that takes I don't know, but it must come off to access the door latch, there you will likely find the latch release control rod has come off or the latch is defective.

Remove interior door panel and inspect linkage.

Won't open from outside? Won't open from inside? Equipped with power door locks? IF so, and won't open inside/outside, suspect stuck power door lock actuator. Sometimes working the lock/unlock button will make the door unlock. If not, the door will require disassembly from inside to determine what the failure may be. If the door needs disassembly while in the closed position, the paneling/clips may get damaged FYI

Have to open the door & then remove the door panel,
to see what the issues are, with the inside or outside
lock mechanism

Then buy the required parts at a dealer or salvage yard

Close/wind up the window. Remove the inside door panel. Be careful with power window switch and door speaker wiring connectors. Disconnect them before pulling the door panel away. Remove any plastic covers that may be glued to the door. Have a look at the door handle from inside the door. You will have some idea as to how to remove it. Usually door handles are secured by screws from the inside. Locate and remove them. Remove linkages to the door handle then pull handle form outside.

take your door panel off and see if your cable is connected to the inside door handle. It does open from the outside right? If your cable is connected or if the door does not open from the outside either, you will need to replace your door lock actuator.

You may be able to remove the front fender and drive the pins out of the door hinge.

can it open from the outside? There is a child safety lock inside the door when open it could have been put on child proof not allowing a young child to open the door from the inside but it will still open from outside. if this is not the problem then your rod has disconnected from the latch mechanism inside the door, you may need a slim jim tool or try to remove door panel from inside, this will be difficult when door is shut but maybe possible depending on the door panel itself, they may have some screws but most just snap in.

Probably the lock in the latch.
You'll have to remove the inside door panel to get to the latch.

The rods in the drivers door probably came off.
Somehow you got to take the door panel off from the inside and look.