Does it happen at miscellaneous times, or is it at specific times, i.e., when you hit a certain speed, etc? If it's intermittent, then you may need to replace or clean the switch for the door locks. If it's at a certain speed, then most Chevrolet cars and trucks past about 1998 or so will have an automatic locking device that keeps kids from escaping while the car's in motion. They can be programmed to actuate at different times, so you may want to look at your owner's manual to see how to set yours, if you feel that it could be this.
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