It could be a faulty Camshaft Position Sensor. It could be sending an intermittent signal confusing the car's ECU.
You didn't state the year but could be a couple of issues. First, could have have a cam jump 1 tooth and it is now out of time. Second, you could have a cam or crank sensor failing and they are not syncing. Third, you could have a pcm/ecm failure or issue. Did you get a reference code?
SOURCE: 1996 Jeep GC - Diagnostic tool identified cylinder misfire
P0300 Code - Random Misfire
Symptoms
Symptoms may include:
Causes
A code P0300 may mean that one or more of the following has happened:
SOURCE: 2002 grand am 4 cylinder rough idle and rough running
Check the ignition control module. Sounds like the exact same problem I have had with mine. Took it to the dealership and the were able to tell me right away. The ignition control module is very easy to replace and is located on the top of the valve cover. Hope this helps!
SOURCE: 1998 Audi A4, engine shakes/runs rough sometimes
sounds more like a air control /sensor but its difficult to diagnose from spain without seeing the car ,sorry for being able to give a quick fix
SOURCE: Engine runs rough at idle and slow speeds.
clean the idle air control with brake cleaner or carb cleaner
SOURCE: 2003 cadillac cts 3.2 liter..rough idle, scan tool
Did you ever find a solution to this? I am having the same issue on 2,4,6. I have replaced the coils. checked the intake for vacuum leaks. I am lost here let me know if you find anything and I will do the same.
Generic OBD II Diagnostic Trouble Codes
DTC CODES P0300 to P0399
P0300....Random/Multiple Cylinder Misfire Detected
P0301....Cylinder 1 Misfire Detected
P0302....Cylinder 2 Misfire Detected
P0303....Cylinder 3 Misfire Detected
P0304....Cylinder 4 Misfire Detected
P0305....Cylinder 5 Misfire Detected
P0306....Cylinder 6 Misfire Detected
P0307....Cylinder 7 Misfire Detected
P0308....Cylinder 8 Misfire Detected
P0309....Cylinder 9 Misfire Detected
P0310....Cylinder 10....Misfire Detected
P0311....Cylinder 11 Misfire Detected
P0312....Cylinder 12 Misfire Detected
P0313....Misfire Detected with Low Fuel
P0314....Single Cylinder Misfire (Cylinder not Specified)
P0320....Ignition/Distributor Engine Speed Input Circuit
P0321....Ignition/Distributor Engine Speed Input Circuit Range/Performance
P0322....Ignition/Distributor Engine Speed Input Circuit No Signal
P0323....Ignition/Distributor Engine Speed Input Circuit Intermittent
P0324....Knock Control System Error
P0325....Knock Sensor 1 Circuit (Bank 1 or Single Sensor)
P0326....Knock Sensor 1 Circuit Range/Performance (Bank 1 or Single Sensor)
P0327....Knock Sensor 1 Circuit Low Input (Bank 1 or Single Sensor)
P0328....Knock Sensor 1 Circuit High Input (Bank 1 or Single Sensor)
P0329....Knock Sensor 1 Circuit Input Intermittent (Bank 1 or Single Sensor)
P0330....Knock Sensor 2 Circuit (Bank 2)
P0331....Knock Sensor 2 Circuit Range/Performance (Bank 2)
P0332....Knock Sensor 2 Circuit Low Input (Bank 2)
P0333....Knock Sensor 2 Circuit High Input (Bank 2)
P0334....Knock Sensor 2 Circuit Input Intermittent (Bank 2)
P0335....Crankshaft Position Sensor A Circuit
P0336....Crankshaft Position Sensor A Circuit Range/Performance
P0337....Crankshaft Position Sensor A Circuit Low Input
P0338....Crankshaft Position Sensor A Circuit High Input
P0339....Crankshaft Position Sensor A Circuit Intermittent
P0340....Camshaft Position Sensor 'A' Circuit (Bank 1 or Single Sensor)
P0341 Camshaft Position Sensor 'A' Circuit Range/Performance (Bank 1 or Single Sensor)
P0342....Camshaft Position Sensor 'A' Circuit Low Input (Bank 1 or Single Sensor)
P0343....Camshaft Position Sensor 'A' Circuit High Input (Bank 1 or Single Sensor)
P0344....Camshaft Position Sensor 'A' Circuit Intermittent (Bank 1 or Single Sensor)
P0345....Camshaft Position Sensor 'A' Circuit (Bank 2)
P0346....Camshaft Position Sensor 'A' Circuit Range/Performance (Bank 2)
P0347....Camshaft Position Sensor 'A' Circuit Low Input (Bank 2)
P0348....Camshaft Position Sensor 'A' Circuit High Input (Bank 2)
P0349....Camshaft Position Sensor 'A' Circuit Intermittent (Bank 2)
P0350....Ignition Coil Primary/Secondary Circuit
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