How do you run a HVAC calibration for a 2006 Chev Impala?

HVAC calibration ???? For What , mode door or temp door actuator ? Actuator Replacement
If an actuator is replaced, the following procedure must be performed: Re-Calibrating Actuators. Refer to Actuator Recalibration in HVAC Systems Manual.
Actuator Recalibration Calibration Procedure
Use the following steps to perform the calibration update:
Install a scan tool.
Turn ON the ignition, with the engine OFF.
Select HVAC Control Module
Select Special Functions
Select recalibrate All Motors
Select ON, wait 60 seconds.

Or the HVAC control module ?
HVAC Control Module Replacement
If the HVAC Control Module is replaced, the following procedure must be performed: Reprogram the HVAC Control Module. Refer to Service Programming System (SPS)

For either one you need to take to the dealer or someother qualified repair shop