When driving my 2006 E350, I have no acceleraton. Transmission appears to be slipping. I would have to turn the car off and restart.

SOURCE: overdrive transmission

O/D light flashing is computer indicating an issue with the transmission -no surprise. Make sure the transmission fluid is still good (dosn't smell burnt, right level). Slipping could be the TCC (torque Converter clutch) - not a cheap part - but would only really slip in 4th gear (above 40 mph). Slipping before that could be numerous things in the trans (low fluid pressure, torque converter issues).
I would be tempted to replace the fluid anyhow, but there is a chance an expensive issue is starting to arise - and replacing the fluid on a failing transmission could cause it to fail 100% (or can fix it nearly 100%). These can be touchy transmissions, too much DIY without the right diagnostic tools can be bad. Not what you wanted to hear, and not an expert, but have had some expertise with these.hope that helps.

SOURCE: I have a 1990 Acura

I am very excited because I have the same problem and thought it was transmission but went to my mechanic today and he found that some computers were giving codes on my car. One computer module is under Right Passenger seat, turn key on but do not start car and read how many times that light flashes, then ask mechanice to tell you what the code means. In my case what is causing the tranny to slip is the need for a new speed sensor control module. So, you may just need one of those too instead of a new tranny. !!!! Since my Legend was flashing a code 15, my mechanic pulled the fuse that you are supposed to pull when this 15 code comes up and hold it out of fuel box for 10 seconds and then put it back in. This reset the computer and then it showed no code, (no flashing light.) He told me to drive it for awhile and then check again to see if a code was flashing. If nothing flashes then you are OK. If it does flash, count number of times it flashes and tell the mechanic. If the light flashes, it means it is a "code". If it flashes 15 times it is a speed control sensor messing up the transmission capability and just needs the speed control sensor replaced!!
He also checked a computer under the rug of the passenger side dashboard under the glove box. It was flashing a 2, (2X). He pulled the fuse that corresponds to that and held it out for 10 seconds to reset it, and now it does not flash, ie shows no code, so that is fine. But check those 2 computers on your Acura to see if it is giving you flashing light in either of them, and if so, count how many times it flashes, and then you will know if it is really the transmission.

My car runs a HECK of a lot better now that he reset the codes. I think something got "off" when my alternator was replaced and they had to be reset.

I am thrilled I won't have to replace transmission!!

SOURCE: Transmission is Slipping

Without knowing the year, engine size, etc., I can only make educated guesses, but here goes: You stated "My car will drive, but very slow hardly moving". My first suspicion is that you don't have a transmission problem, but the car is in what Chrysler calls the 'limp-home mode'. This occurs when the computer 'sees' a problem with an engine function or sensor that is serious, but not so bad that the car won't run at all. Limp-home mode allows your car to only operate in second gear so that you won't damage it further by driving normally, but won't leave you stranded either. Is your 'check engine' or 'service engine' light on? If not, check to see that it actually works by turning the key 'on', but not starting the car. All the dash lights should be lit for about 3-5 seconds. No matter what, you need to check your transmission fluid level (on a Crysler, should be checked with the engine running and in gear, NOT park or nuetral). Safety first, make sure someone is holding the brake on - please don't ever trust a 'parking brake' for this. If the fluid level is OK and there's no 'check engine' light you need
to visit a competent transmission shop. Probabably a worn front pump, torque converter, or a hung spool valve in the valve body, none of which is generally fixable at home. If you do have a 'check engine' light on, see a regular mechanic first as there is a mechanical problem probably not related to the transmission. Good Luck!

SOURCE: slipping transmission when hot

Check the fluid level and make sure it is up.If o/k then suggest a trans service which will have the filter and fluid changed. This could be your problem.

SOURCE: turning corner transmission slips- v-6 rear 2

If the fluid is low it will **** air when you go around a corner. If it's not low and you've had the fluid changed than someone forgot the O-ring on the filter.