I need a tune up for my 2000 buick lesabre. What should I be expecting them to fix / change and how much would I typically face cost wise

You should have the plugs, plug wires, air filter if needed, pcv valve, fuel filter, also check for any vacuum leaks, there is a website and app for your phone called repair pal it will not only tell you what you should do to your car at what milage but also tell you what the labor rates are in your area. Check out the site, Good Luck!

They should replace the plugs, fuel filter, check and replace the air filter if its dirty, as far as cost every shop has a different hourly rate and their mark up on parts is different as well. you could be looking at around 200. this is just a guess.