Why vehicle hesitate while driving on the interstate going around 60-65 mph,lose power of sorts are stubble.

I would start with a simple tune-up if you haven't done one recently. Nothing too technical on most vehicles (my Honda was a pain to remove the rotor button).
Get new sparkplugs properly gapped, new distributor cap and rotor button, and a new air filter. You may be dropping a cylinder when you're going down the road. A simple tune-up (if one has not been performed in the past year) can help solve many problems. It can also help if troubleshooting an issue. Most people don't think about replacing things like sparkplugs until they have a problem. Manufacturers usually give a recommended mileage for the change interval. And no, not all spark plugs are the same. Some vehicles are extremely particular about what spark plug you use.

Your description sounds more like a torque converter clutch problem. It would explain the poor mileage, having to floor it to go. I suggest having the transmission scanned, looking at the slip speed of the torque converter clutch.

Engine misfire - spark plug or spark plug wire maybe . Tune - up ,ever had this done ? Does the check engine light come on steady or flashing ?

plastic distributor ? wrong screws in rotor? timing?

I have a 1993 Taurus GL V6 3.0L..I"am experiencing a loss of power. Hesitates on acceleration Only when It's cold.When is get hot it runs very good. I have Replace Spark Plugs Cap & rotor were change air filter & fuel filter & TPS/EGR..... & it has a rebuilt ENG in it...this could be a sensor. But which one could it Be?

What Can This Be?

P0300 Random/Multiple Cylinder Misfire Detected
P0404 Exhaust Gas Recirculation Circuit Range/Performance
P0207 Injector Circuit Malfunction - Cylinder 7
P0500 Vehicle Speed Sensor Malfunction
P0600 Serial Communication Link Malfunction

Go to www.obd-codes.com

Improper spark plugs installed or weak coil.

sounds like the ignition module is going bad.

Try the fuel filter. If you have had the plugs, wires changed it may be the fuel filter.

Replace plugs and wires, especially if the missing is worse at high throttle, and definitely if the check engine light *blinks*. The plugs might make it to 100k miles on this engine, but the spark plug boots can carbon track before then.