2005 GMC Canyon 4x4 clicking noise in rear end when in drive. Starts at about 20mph. At first, noticed a squeeking noise when in reverse. that went away.

Put a code reader on it should tell you a code for powertrain

hello,
with out more info it sounds like it could be the drive axle could be going bad if it's a 4x4 or possibly one of the pins holding the brake caliper in place has backed out and rubbing the inside of the wheel. I would also check the wheel bearings to make sure the wheel is not loose and making the noise you hear.

get it inspected, noise many times means big trouble.
are the lug nuts loose?
bad u-joint (hand checked)
or road hazard damage (hit)
? look first. see whats there,

have you tried to give the bushing a good greasing?

tyr disconnecting the battery with the trunck in 2 wheel mode, leave off for 1-2 min. then reconnect and try again, there may also be a software update required to solve this!

Check for broken wires.

your description sounds like the gears inside the the same differential you just replaced.

this kind of noise is useualy caused by the rear most U joint.

check body mount bushings if just a little loose will cause to squeek.

rear drive shaft steady bearing rubber mount gone