I HAVE A 99 HONDA ACCORD V6 WITH 250K MILES. WHILE DRIVING AT 70MPH I WILL LOOSE POWER WHILE THE ENGINE IS STILL RUNNING AND THEN A COUPLE OF SECONDS, POWER IS BACK. THE PROBLEM IS INTERMITENT, HAPPEN EVERY NOW AN THEN, BUT DAYS OR WEEKS COULD GO BY WITHOUT IT HAPPENING AGAIN. COULD THIS BE A PROBLEM WITH THE MAIN RELAY?

SOURCE: Main Relay on 92 Honda Accord

HI...
On you Honda Accord the main relay is located.
On left side of dash, under the Instrument Panel. Left side of the Steering Column.
To get axces You will need to Remove the Cruise Control Module. That is attached with 2, 10mm screws. one on the Steering column, the other one at the dash braket.
after you remove the cruise control module, you will see a Little Box Gray colour, Is a Relay more biger than a Regular Relay.
The NUMBER on the RELAY is : RZ0088.

OK.. I hope this help on your question.
Thank you for use fixya.

SOURCE: 1991 Honda Civic DX starting problem

normally that happens with a fuel pump going bad or your ignition coil gets to hot n shuts down. when it happens again, take your spark plug wire off, have someone to help you start the car if no spark its gotta be your fuel pump

SOURCE: 1997 Honda Accord Main Relay problem

How about the ignition cylinder? Have you replaced that?

SOURCE: Re: 2000 Honda Accord

how often do u drive ,i use this remedy to cure flooded engines,which can occur in coldre weather mainly if started then turened off immediatly,weak battery/lack of use,or if the accelerater is depress when starting.

SOURCE: 1988 honda accord runs for 10-20 min, then loses engine power

Have you checked your alternator?