1986 f150 4x4 5.0 manual runs and ides fine but when you accelerate and shift gears it jerks and sputters

SOURCE: 1990 f150 sputters after warmed up.

Replace the fuel filter.

SOURCE: 1998 astro sputtering when taking off and while at driving speed

loose vacuum line, check for same, also check the map sensor and the measure the fuel pressure, make sure its at spec

SOURCE: 1992 Siera k1500 4x4 Replaced rotor, distributor

Have you checked fuel pressure? 12 psi?

SOURCE: I got a 99 tahoe 5.7 vortec with multiple misfires

this is one of those situations that a professional diag would of saved you alot of money. Its possible you just got bad gas and your injectors are partially clogged. An 02 sensor would not give multible misfires. EGR would only misfire at idle if stuck partially open since its suppose to be open cruising. Fuel filter would give you a starvation issue but if the misfires happens at idle then the filter most likley is ok.
Data from a professional data scanner will store the conditions when the misfire occurs. Also for a chevy each cylinder will have a misfire counter and one can see the misfire happening as it happens. If its idling and misfiring and gets better as you rev it up most likely you have clogged injectors or a intake vacuum leak. You can test for a intake leak by spraying the intake area with water(idle will faulter if it draws water in), or use brake cleaner (idle will raise when fluid gets drawn in).

If no leaks are found I would do an injection service or at least add two bottles of techron to a full tank, drve till half a tank then top off again.

Also if the catalytic converter is clogged the backpressure could cause all sorts of misfire issues. Removing the two upfront 02 sensors and driving will indicate the exhaust is clogged or not. We put a pressure sensor in place of the 02 sensor. If the pressure is above 5psi this would indicate some blockage. It should be below 3psi at 2000 rpm. Also if you have K/N filter the oil from it will coat the maf sensor wires in time,, (always). You can remove the sensor and spray the wires with brake cleaner to clean. DO NOT touch them. They can be brittle. Look at the wires for color. They should be shiny silver. If its coated the PCM will not see the air volume or accurately see the air temperature. Without this information the PCM will not add enough fuel which will create a misfire.

SOURCE: 1992 Siera k1500 4x4 Replaced rotor, distributor

You may want to inspect your vacuum hoses. Look for missing, brittle, or cut hoses and replace them.