Safe mode problem

I watch a lot of Law and Order, it the first one always.

Make sure that tire and rim hadn't been rotated to the spare

Double clutch transmission operationDriving your vehicle Automatic...

Warnings and indicatorsFeatures of your vehicle Instrument cluster...

If you have an external fuel filter, good idea to replace and then take for test drive. If problem still present, might want to cheek fuel pressure.
There are a few other components that could cause your issue. A fuel pump that may be going bad or there is lots of dirt inside fuel tank. Another problem could be a bad fuel pressure regulator.
Do you have any codes in your engine control module ?

I had a similar problem with my Santa Fe. It occurred intermittently but after I turned the steering wheel to the left. After much screwing around by the dealer and trying to baffle me with BS we heard about a strange solution. I am not a mechanic but the problem somehow related to a spring in the Airbag on the steering wheel. Changed the spring and "Stone the flame'n crows" problem solved. Never had a problem since.

engine manage lights and limp mode are activated from the engine AND the transmission faults
may be the mechanic is looking in the wrong area for the fault as it could be a TCM or wiring problem in the transmission
discuss it with MB headquarters technicians as the local shop may not have the experience to fix problems

Well, I agree, MB should have been able to resolve the issue. Next items to check are all tire pressures and then the brakes. Typically the tech will want to drive your car before and after an alignment, so this is strange...

do u have a check engine light on? does it shift hard when you put it in drive. does it go in the limp mode ? it is usually the conductor plate in the transmission. it is called the electrics kit by mercedes. it is in the valvebody of the transmission. not hard to replace.

hi,is this problem come after you repair your ecu,if is yes ,maybe the repair is not perfect,or you may check your fuel filter for water contamination,ty

please check whether you put "W"(Winter mode) instead of "S" .....