Driver side door will not unlock with key or with keyless entry

What alarm ? Horn an do the lights flash ?
The content theft deterrent (CTD) system, when armed, is designed to deter vehicle content theft by pulsing the horns and exterior lamps for approximately 30 seconds when an unauthorized vehicle entry is detected. However, the CTD System does not affect engine starting.
An unauthorized entry can be any of the following with the CTD System armed:
• When the liftgate or liftglass has been opened without the use of the keyless entry system or without first being unlocked.
• When any door is opened without first being unlocked using the keyless entry transmitter.
• When the driver door is opened without being first unlocked using the driver door cylinder.
The components of the system are:
• The body control module
• The door ajar switches
• The driver door key cylinder switch
• The liftgate/liftglass ajar switch

Disarming an Armed System/Silencing an Alarm
If system arming has occurred, it must be disarmed.
Important: Manually unlocking the doors does not disable the content theft deterrent (CTD) armed mode. Also, disconnecting the battery or pulling fuses does not disable the armed mode, as the BCM stores the CTD status in memory.
To disarm the CTD system perform one of the following:
• Press the UNLOCK button on the keyless entry transmitter.
• Unlock the driver door using the door key cylinder.
• Insert a valid key into the ignition and start the vehicle.

Inside the driver door latch, there is a switch for the key that tells the system, the key switch is on or off position but usually, the wires are cut or if you prefer open circuit.
BUT you didn't mention if you try to unlock the door with your key or with the keyless entry??
Can you unlock the driver's door with the inside switch if not look for door lock problems?

Hope it helps

Try this

2004 XL7

1. Remove key from ignition switch.

2. Close all doors.

3. Open drivers door

4. Insert key and turn to ON position and within 10 seconds turn
key off and remove key.

5. Within 20 seconds Close and open drivers door 3 times.

6. Insert key and turn to ON position and within 10 seconds turn
key off and remove key.

7. Locks should now lock and unlock automatically to confirm you
have entered programming mode.

8. Press the UNLOCK button on remote and locks should cycle to
confirm programming.

9. Repeat step 8 on each additional remote.

10. Exit vehicle with keys and remote, close door test remote(s)

Common problem, a small switch in the door lock breaks and does not activate the lock, all works from the key not remote, driver door recognises door not locked will unlock all doors, to repair you have to replace drivers door lock or just live with the key, I do
Merry Christmas

hi
Chance are the driver side control module is not working.
Open the driver side, inner door panel and check

Programming
When
Remote control added or replaced. System malfunction.
How
Obtain all remote controls. Remove key from ignition switch. Close all doors. Open driver's door. Carry out the following within 24 seconds: Turn ignition switch ON and back to LOCK position 3 times. Remove key. Press and release driver's door courtesy light switch 3 times. Ensure doors lock and unlock. If not, wait 40 seconds and repeat procedure starting with driver's door already open. Press each remote control lock or unlock button twice. Ensure doors lock and unlock after each remote control operation. If not, proceed as follows: Press and release driver's door courtesy light switch once. Ensure doors lock and unlock twice. Repeat procedure starting with driver's door already open.
NOTE: A maximum of 3 remote controls can be programmed.

counds like dirty contacts in the door frame

lock actuator is bad...

If you have tried the inside, and outside door handle, and it does not open you need a new door latch assembly.

inspect and or replace the drivers door lock actuator...