I have a 2000 Dodge durango and i keep getting the cylinder 5 misfire code. we have changed the plugs, wires, distributor cap, and injector. I dont know what else to do! it is only coming on number 5

Same cylinder all the time? What brand of spark plug did you put in? Have you cleaned injector connection? If spark plug and wires are known good, injector and connection would be next. Did you erase code after other work done?

Check your coil pack. Sounds like one or two need replacing.

I WOULD REPLACE DISTRIBUTOR CAP AND ROTOR.MARK LOCATION OF ROTOR OR MAKE NOTE SO YOU CAN INSTALL NEW ROTOR IN CORRECT FIRING POSITION. IF THIS CAR HAS A LOT OF MILES I WOULD REPLACE DISTRIBUTOR CAP, ROTOR.SPARK PLUGS AND WIRES.REPLACE IGNITION COIL.CLEAN FUEL INJECTORS, FILL GAS TANK UP TO 3/4 TO FULL TANK OF GAS POUR CAN SEAFOAM IN FUEL TANK IT WILL FLUSH OUT THE FUEL INJECTORS WHILE ENGINE RUNNING OR DRIVING CAR. REPLACE FUEL FILTER. REASON I SAY DO A TUNE UP PROBLEM COULD BE MINOR FIX.COULD NEED TUNE UP.IF TUNE UP DONT HELP THEN YOUR PROBLEM IS DISTRIBUTOR OR THE CAMSHAFT SENSOR INSIDE OF DISTRIBUTOR.THAT WOULD SET OFF CHECK ENGINE LIGHT.BUT I WOULD SAY TUNE UP COULD FIX PROBLEM.

Hi, there are 2 common reasons for a single cylinder misfire you have not addressed it: faulty fuel injector and burnt valve.
You need a voltmeter to test the injector:
Check the resistance across the injector terminals. It should be about 12 ohms. If open or shorted, replace the injector.
After removing an injector, apply 12 volts DC across the terminals. A "click" should be heard. If not, replace the injector.
If ok, then you need to do an engine compression leakdown test with cylinder compression gauge. if compression leaks down in that cylinder, then you have a burnt valve causing the misfire

po 300 is random/ multible cylinder misfire detected po507 idle system rpm high-- go to this site for the po507 meaning--www.obd-codes.com/p507 === please go to this site for the po300 code---- www.obd-codes.com/p0300

Random/Multiple Cylinder Misfire Detected have a good day !!

P0201?? Injector #1 Ctrl Circ /
P0207 Injector #7 Ctrl Circ /

P0300?? Multiple Cylinder Misfire
P0301?? Cylinder #1 Misfire
P0307?? Cylinder #7 Misfire
are the codes start with the basics inspect plugs wires cap rotor and if all checks out do a compression test

If you already replaced the wires, I would suggest replacing the plugs, distributor cap and rotor. They are also very important parts of the spark. Fuel injector problems can also cause misfires.

if u change plug wires ,coils ,plugs and still having problems check the injecter with a pulse light the one that dont pulse the pcm is bad are broke wire if all of them are pulseing then change the injecter.had the same problem on a 2000 s10 2.2

Aloha We have just replaced all of what you have replaced, plus water pump, fuel pump, pcv valve and 02 sensor. Took it to mechanic today we had misfire on 1,2,6,7. Mechanic said that the 99 dodge is known for bad computers, he checked ours and works great turns out that it was the coil. Ours was jumping 1/4 inch and had a orange/yellow spark. it is supposed to have a 1 inch spark and be blue. This has solved our problems after 527 dollars later.
Check the coil!