How to Drive a Toyota Prius?
Like any other car.
You have to make sure the "key" is in your pocket or within range of the "key sensor," and push the start button, lower right of the wheel. Then you just put it in drive, and drive like a normal car. If you have the "ECO" setting, you can push the button and the internal combustion engine will be less aggressive, which saves gas. If you're in traffic and say, want to be able to pull away from a stop or turn left in heavy traffic, just pop it out and the combustion engine will react more aggressively to get you through the intersection when you give it gas.
Other than that, it's just a regular car. They're great; you can cruise on the interstate at 75mph+ all day long and get around 50mpg. The only thing to keep in mind when pushing it around at speed somewhat aggressively on curves, is that the tires have less contact surface that actually meets the road. In other words, they're skinny. Less contact surface touching the road means less resistance, which increases mpg. Other than that, it's just a car.